A ground-breaking genetic study in Asian women led by Malaysian scientists in collaboration with Singapore and the 188体育网址_188体育在线-【唯一授权网站】@ of Cambridge revealed that a genetics tool developed to help European women assess breast cancer risk also works in Asian women.

The tool, called a Polygenic Risk Score (PRS), separates people into different risk groups based on their genetic sequence, to predict their future risk of developing breast cancer. The results can empower women to decide which screening and prevention is right for them, and help reduce inefficiency, unnecessary cost, and even possible harm caused by over-diagnosis.

“This is the first large study of the PRS in an Asian population. Previously, Asian studies were nearly six times smaller than studies in European women, and due to lack of data in Asians, it was unclear if PRSs are effective in predicting breast cancer risk in non-European women. Through the significant increase in data from Malaysia and Singapore, we now know PRS can help us identify more accurately who is at high risk of breast cancer. Our results suggest that only 30% of Malaysian and Singaporean women have a predicted risk similar to that of European women, and that using the PRS accurately identifies these high-risk women,” said Professor Datin Paduka Dr Teo Soo Hwang, OBE, Chief Scientific Officer at Cancer 188体育网址_188体育在线-【唯一授权网站】@ Malaysia and co-lead of the project.

The collaborative study, published in the prestigious Nature Communications science journal, was the result of a collaboration between Cancer 188体育网址_188体育在线-【唯一授权网站】@ Malaysia and Associate Professor Ho Weang Kee, 188体育网址_188体育在线-【唯一授权网站】@ of Nottingham; Professor Douglas Easton and Professor Antonis Antoniou, 188体育网址_188体育在线-【唯一授权网站】@ of Cambridge, UK; Professor Nur Aishah Mohd Taib, Universiti Malaya; Professor Dato’ Dr Yip Cheng Har, Subang Jaya Medical Centre; Associate Professor Mikael Hartman, National 188体育网址_188体育在线-【唯一授权网站】@ Health System, Dr Li Jingmei, Genome Institute of Singapore, and six hospitals in Singapore; and a large population-based prospective cohort from Singapore.

“Combining genetic factors into one comprehensive model is critical to move from the research to a tool for women to use. We evaluated the PRS in 45,212 Asian women, from Singapore, Malaysia, Japan, Korea, China, Hong Kong, Thailand, Taiwan, USA, and Canada. Studies such as these require large sample sizes, and so, bringing together patients from 188体育网址_188体育在线-【唯一授权网站】@ Malaya, Subang Jaya Medical Centre, National 188体育网址_188体育在线-【唯一授权网站】@ Hospital, Singapore, and six other major treatment centres in Singapore really gave us the sample size to be able to evaluate the tool in Asians,” said Associate Professor Ho Weang Kee, first author of the study.

“Our study is a critical piece of the puzzle that helps us better understand breast cancer risks in different women around the world. There are differences in the genetic make-up of Asian women compared to women of European descent, which means their propensity to develop breast cancer may be different. Understanding this can help us to work out why some women are at higher risk of the disease, which in turn should help us to improve screening, prevention and ultimately treatment of the disease,” said Professor Douglas Easton, Director of the Centre for Cancer Genetic Epidemiology, 188体育网址_188体育在线-【唯一授权网站】@ of Cambridge, and co-lead of the study.

“We have been developing a model for predicting breast cancer risk in European women that includes the PRS and this is now approved for clinical use. This study is the first big step towards enabling the use of such tools in the clinical management of women of Asian ancestry,” said Professor Antonis Antoniou, 188体育网址_188体育在线-【唯一授权网站】@ of Cambridge, and co-lead of the study.

Women are generally recommended to start screening at age 50. However, in most Asian countries, many women who could be at risk of breast cancer do not go for screening. This leads to late detection and a lower survival rate.

“The Polygenic Risk Score is an important step forward and lays the foundation for risk-based mammography screening in Singapore,” said Associate Professor Mikael Hartman, National 188体育网址_188体育在线-【唯一授权网站】@ Health System, Singapore.

“Risk-based screening may be particularly important in low- and middle-resource countries that do not have population-based screening, such as Malaysia. Without the funding for population-based screening, identifying individuals with higher risk may be an important strategy for early detection,” said Professor Nur Aishah Mohd Taib, Universiti Malaya Cancer 188体育网址_188体育在线-【唯一授权网站】@ Institute, Malaysia.

There is an urgent need to develop an appropriate screening strategy for Asian women. Malaysia anticipates a 49% increase in breast cancer cases from 2012 to 2025. Malaysia has a much lower five-year survival rate compared to other Asian countries at only 63%, whereas South Korea is at 92% and Singapore is at 80%.

“188体育网址_188体育在线-【唯一授权网站】@ collaborations like this are extremely important, bringing together data and expertise from the UK and Malaysia to help find solutions to one of the world’s leading causes of death – cancer,” said His Excellency Charles Hay MVO, British High Commissioner to Malaysia.

The study was supported by numerous research grants and charitable funding, principally from the Medical 188体育网址_188体育在线-【唯一授权网站】@ Council and Academy of Sciences Malaysia via the Newton-Ungku Omar Fund, the Wellcome Trust Collaborative Science Award, Yayasan Sime Darby, Yayasan PETRONAS, and Estee Lauder Group of Companies.

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For media enquiries please contact: Josephine Dionisappu, PR and Communications Manager 188体育网址_188体育在线-【唯一授权网站】@ of Nottingham Malaysia at josephine.dionisappu@nottingham.edu.my  

Notes to editors: The 188体育网址_188体育在线-【唯一授权网站】@ of Nottingham is a research-intensive university with a proud heritage, consistently ranked among the world's top 100. 188体育网址_188体育在线-【唯一授权网站】@ at the 188体育网址_188体育在线-【唯一授权网站】@ of Nottingham is a life-changing experience and we pride ourselves on unlocking the potential of our 44,000 students - Nottingham was named both Sports and International 188体育网址_188体育在线-【唯一授权网站】@ of the Year in the 2019 Times and Sunday Times Good 188体育网址_188体育在线-【唯一授权网站】@ Guide, was awarded gold in the TEF 2017 and features in the top 20 of all three major UK rankings. We have a pioneering spirit, expressed in the vision of our founder Sir Jesse Boot, which has seen us lead the way in establishing campuses in China and Malaysia - part of a globally connected network of education, research and industrial engagement. We are ranked eighth for research power in the UK according to REF 2014. We have six beacons of research excellence helping to transform lives and change the world; we are also a major employer and industry partner - locally and globally.