Contact
- workRoom B1C17 Block B1
Malaysia Campus
Jalan Broga
43500 Semenyih
Selangor Darul Ehsan
Malaysia - EeSoo.Lee@nottingham.edu.my
Biography
Ee-Soo Lee completed her Bachelor of Science (Hons) degree with a major in Biochemistry at the 188体育网址_188体育在线-【唯一授权网站】@ of Malaya, Malaysia. During her undergraduate studies, she developed a diagnostic kit for detecting biomarkers in the serum of cancer patients. At the same university, she obtained a Master of Medical Science degree in Molecular Genetics through her research on the alteration of the p16 tumor suppressor gene in lymphoma. She was awarded Ubbo Emmius Scholarship and pursued her PhD studies in Vascular Biology at the 188体育网址_188体育在线-【唯一授权网站】@ of Groningen, the Netherlands, focusing on biomechanical regulation of endothelial phenotype. She joined the National 188体育网址_188体育在线-【唯一授权网站】@ of Singapore as a 188体育网址_188体育在线-【唯一授权网站】@ Fellow and completed her postdoctoral training in Adipose Tissue Biology. She investigated the role of activin receptors, ALK4 and ALK7 in the regulation of fat metabolism and obesity. Thereafter, she was appointed as a Senior 188体育网址_188体育在线-【唯一授权网站】@ Fellow at Nanyang Technological 188体育网址_188体育在线-【唯一授权网站】@ Singapore, where she examined the mechanism of ACKR1 in endothelial injury among COVID-19 survivors. In 2023, the American Heart Association recognized her work on ACKR1 with the Paul Dudley White International Scholar Award. She obtained a Higher Education Teaching Certificate from the Derek Bok Center for Teaching and Learning, Harvard 188体育网址_188体育在线-【唯一授权网站】@, United States. Since 2024, she has been a lecturer in biology and physiology, and an Assistant Professor at the School of Pharmacy, 188体育网址_188体育在线-【唯一授权网站】@ of Nottingham Malaysia.
Teaching Summary
Ee-Soo Lee's teaching philosophy is rooted in the belief that education is a transformative and lifelong experience that empowers individuals to grow intellectually, professionally and personally who… read more
188体育网址_188体育在线-【唯一授权网站】@ Summary
Ee-Soo Lee's research aims to elucidate and intervene in the mechanisms through which adipocytes and endothelial cells contribute to age-related vascular disorders. Currently, her studies focus on… read more
Recent Publications
- ES LEE, N NGUYEN, BE YOUNG, H WEE, V WAZNY, KL LEE, KY TAY, LL GOH, FW CHIOH, MC LAW, IR LEE, LT ANG, KM LOH, MY CHAN, BE FAN, R DALAN, DC LYE, L RENIA and C CHEUNG, 2024. Inflammatory risk contributes to post-COVID endothelial dysfunction through anti-ACKR1 autoantibody. Life Science Alliance. 7(7), e202402598
- EA TAY, V VIJAYAKUMAR, RF MORALES, ES LEE and A TEO, 2024. Protecting the endothelial glycocalyx in COVID-19. PLoS Pathogens. 20(5), e1012203
- PH LIN, C HUANG, Y HU, VS RAMANUJAM, ES LEE, R SINGH, U MILBRETA, C CHEUNG, JY YING and SY CHEW, 2023. Neural cell membrane-coated DNA nanogels as a potential target-specific drug delivery tool for the central nervous system. Biomaterials. 302, 122325
- ES LEE, T GUO, RK SRIVASTAVA, A SHABBIR and CF IB??EZ, 2023. Activin receptor ALK4 promotes adipose tissue hyperplasia by suppressing differentiation of adipocyte precursors. Journal of Biological Chemistry. 299(1), 102716
Ee-Soo Lee's teaching philosophy is rooted in the belief that education is a transformative and lifelong experience that empowers individuals to grow intellectually, professionally and personally who can live life to the fullest and make contribution to mankind. She believes that education should develop self-confidence, inspire critical thinking, foster creativity and instill a lifelong passion for learning in students. Currently, she teaches biology and physiology courses for the Bachelor of Pharmacy (Hons), Master of Pharmacy (Hons) and Bachelor of Science (Hons) in Biomedical Science programs at the School of Pharmacy.
Current 188体育网址_188体育在线-【唯一授权网站】@
Ee-Soo Lee's research aims to elucidate and intervene in the mechanisms through which adipocytes and endothelial cells contribute to age-related vascular disorders. Currently, her studies focus on two aspects:
- Transforming growth factor-β (TGF-β) signaling, with an emphasis on ALK4, ALK5 and ALK7 receptors in the regulation of endothelial cell functions and adipose tissue remodeling.
- Investigating the phenotypic and functional changes of endothelial cells and adipocytes in response to extracellular biochemical and biomechanical cues.
- ES LEE, N NGUYEN, BE YOUNG, H WEE, V WAZNY, KL LEE, KY TAY, LL GOH, FW CHIOH, MC LAW, IR LEE, LT ANG, KM LOH, MY CHAN, BE FAN, R DALAN, DC LYE, L RENIA and C CHEUNG, 2024. Inflammatory risk contributes to post-COVID endothelial dysfunction through anti-ACKR1 autoantibody. Life Science Alliance. 7(7), e202402598
- EA TAY, V VIJAYAKUMAR, RF MORALES, ES LEE and A TEO, 2024. Protecting the endothelial glycocalyx in COVID-19. PLoS Pathogens. 20(5), e1012203
- PH LIN, C HUANG, Y HU, VS RAMANUJAM, ES LEE, R SINGH, U MILBRETA, C CHEUNG, JY YING and SY CHEW, 2023. Neural cell membrane-coated DNA nanogels as a potential target-specific drug delivery tool for the central nervous system. Biomaterials. 302, 122325
- ES LEE, T GUO, RK SRIVASTAVA, A SHABBIR and CF IB??EZ, 2023. Activin receptor ALK4 promotes adipose tissue hyperplasia by suppressing differentiation of adipocyte precursors. Journal of Biological Chemistry. 299(1), 102716
- RK SRIVASTAVA, ES LEE, E SIM, CS NEW and CF IB??EZ, 2021. Sustained anti-obesity effects of life-style change and anti-inflammatory interventions after conditional inactivation of the activin receptor ALK7. FASEB Journal. 35(8), e21759
- RK SRIVASTAVA, A MOLINER, ES LEE, E NICKLES, E SIM, C LIU, H SCHWARZ and CF IB??EZ, 2020. CD137 negatively affects "browning" of white adipose tissue during cold exposure. Journal of Biological Chemistry. 295(7), 2034-2042
- ES LEE, LS BOLDO, BO FERNANDEZ, M FEELISCH and MC HARMSEN, 2017. Suppression of TAK1 pathway by shear stress counteracts the inflammatory endothelial cell phenotype induced by oxidative stress and TGF-β1. Scientific Reports. 7, 42487
- JAJ MOONEN, ES LEE, M SCHMIDT, M MALESZEWSKA, JA KOERTS, LA BROUWER, TG VAN KOOTEN, MJA VAN LUYN, CJ ZEEBREGTS, G KRENNING and MC HARMSEN, 2015. Endothelial-to-mesenchymal transition contributes to fibro-proliferative vascular disease and is modulated by fluid shear stress. Cardiovascular 188体育网址_188体育在线-【唯一授权网站】@. 108(3), 377-386
- ES LEE, LH KIM, WA ABDULLAH and SC PEH, 2010. Expression and alteration of p16 in diffuse large B-cell lymphoma. Pathobiology. 77(2), 96-105
- SLL HOE, ES LEE, ASB KHOO and SC PEH, 2009. p53 and nasopharyngeal carcinoma: a Malaysian study. Pathology. 41(6), 561-565
- SLL HOE, ES LEE, ASB KHOO and SC PEH, 2009. Lack of Rb2/p130 genetic alteration in Malaysian nasopharyngeal carcinoma. Malaysian Journal of Pathology. 31(1), 53-56
