Contact

• workRoom B1A05 B1-block
  Malaysia Campus
  Jalan Broga
  43500 Semenyih
  Selangor Darul Ehsan
  Malaysia
• work+6 (03) 8924 8762
• SiuYee.New@nottingham.edu.my

Biography

Dr New Siu Yee received her BSc from 188体育网址_188体育在线-【唯一授权网站】@ of Technology Malaysia (UTM) and her PhD from National 188体育网址_188体育在线-【唯一授权网站】@ of Singapore (NUS). During her PhD study, she was involved in multidisciplinary fields of study with three different research groups and spent a year attachment at 188体育网址_188体育在线-【唯一授权网站】@ of Illinois at Urbana-Champaign (UIUC). After graduated, Dr New worked as Scientist I in Institute Materials 188体育网址_188体育在线-【唯一授权网站】@ and Engineering (IMRE), A*Star, Singapore, before joining the 188体育网址_188体育在线-【唯一授权网站】@ of Nottingham Malaysia. Her current research interest focuses on nanotechnology based biosensors.

Personal research webpage:

https://newsy1019.wixsite.com/newgroup

Expertise Summary

• Crystallization techniques for both small molecules and proteins.
• Various characterization techniques: UV-vis, FTIR, 1D and 2D NMR, electron paramagnetic resonance (EPR), powder X-ray Diffraction (XRD), electrospray ionization-mass spectroscopy (ESI-MS), circular dichroism (CD), spectrofluorometer, surface plasmon resonance (SPR-Biacore), quartz crystal micro188体育网址_188体育在线-【唯一授权网站】@ (QCM), dynamic light scattering (DLS), cyclic voltammetry (CV), thermal gravimetric analysis (TGA), etc.
• Experience in polymerase chain reaction (PCR), protein expression and purification (fast protein liquid chromatography-FPLC),
• Experience in handling Schlenk line, TLC, column chromatography, Soxhlet extraction and vacuum liquid chromatography (VLC).
• Experience in simple modeling using Visual Molecular Dynamic (VMD).

Teaching Summary

MPharm Year 1:

• Essential Skills of Pharmacists (PHAR1010)

MPharm Year 2 - Year Head:

• Gastrointestinal & Liver Disorder (PHAR2016) - Module convenor
• Cardiovascular (PHAR2018)
• Sexual Health and Pregnancy (PHAR2020)
• Renal and Endocrine Diseases (PHAR2019)

MPharm Year 3 188体育网址_188体育在线-【唯一授权网站】@ Project - Module convenor

PHS Year 3:

• Medicinal Chemistry & Drug Design (PHAR3014)

PHS Year 2:

• Pharmaceutical Analysis & Spectroscopy (PHAR2010)
• Concepts in Medicinal Chemistry & Drug Discovery (PHAR2014) - Module convenor

PHS Year 1:

• Laboratories Studies Pharmaceutical Science (PHAR1022)
• Pharmaceutical & Biological Chemistry 1 (PHAR1008)

188体育网址_188体育在线-【唯一授权网站】@ Summary

Principal Investigator/ Main Applicant (UNM)

2019 - 2021: Facile and PCR-Free Detection of miRNA Using Magnetic Separation and Fluorescent Silver Nanoclusters (Fundamental 188体育网址_188体育在线-【唯一授权网站】@ Grant Scheme (FRGS), Ministry of Education (MOE))

2018: SERS Analysis on Reverse Aggregation Control of Cysteamine Coated Gold Nanoparticles (Royal Society of Chemistry; Mobility Grant)

2015 - 2017: Novel Colorimetric & Fluorogenic Nanobiosensors for Telomerase Activity Detection (FRGS, MOE)

2014 - 2015: Systematic Preparation of New Fluorogenic Silver Nanoclusters for Sensing Application (UNMC pump-priming project)

Collaborator

2021 - 2023: Synthesis of protein gold nanoclusters for delivery of silencing-RNA as synergistic colorectal cancer therapy and in situ bioimaging (FRGS, MOE)

2020 - 2021: Colourimetric Nanosensor for the Detection of Ovarian Cancer Biomarker miRNA-665 (MAKNA Cancer 188体育网址_188体育在线-【唯一授权网站】@ Award 2020)

2019 - 2020: Detection of Breast Cancer Biomarker miRNA-155 Using Hybridisation Chain Reaction and Silver Nanoclusters (Taylor's 188体育网址_188体育在线-【唯一授权网站】@ Emerging 188体育网址_188体育在线-【唯一授权网站】@ Grant)

2017 - 2019: Elucidation graphene antimicrobial properties against intracellular Staphyloccoccus aureus from bovine mastitis (FRGS, MOE)

2016 - 2019: Development of Multimode "Turn-On" Protein-Gold Nanoclusters for Targeted Theranostics and Imaging of Colon Cancer and Its Metastases (FRGS, MOE)

Selected Publications

• NEW SIU YEE, CHEUNG EDWIN and SU XIAO DI, 2013. A Method to screen small ligands and determine protein-ligand interactions (Singapore Patent) 201303835-1 05/16/2013 00:00:00
• NEW SIU YEE, SU XIAO DI and TAN YEN NEE, 2013. Protein-Based Fluorescent Metal Nanoclusters for Drug Screening (Singapore Patent) 201306645-1 09/01/2013 00:00:00
• STEVEN LUKMAN, NEW SIU YEE, CHEUNG EDWIN and SU XIAO DI, 2013. A Hybrid Sensor using Metal Nanoparticles and Conjugated Polymers (Singapore Patent) 201303638-9 05/10/2013 00:00:00
• KE LIN, LIM WAI KWAN, NEW SIU YEE, SU XIAO DI and LIU BIN, 2013. Immunosensor Characterization Using Impedance Spectroscopy Journal of Biosensors & Bioelectronics. 4(4),

• View all publications

Past 188体育网址_188体育在线-【唯一授权网站】@

Co-Principal Investigator (IMRE, Singapore)

2012 - 2013: Development of biogenic fluorescent metal nanoclusters for biosensing and clinical diagnosis (IMRE core funded project)

Scientist I (IMRE, Singapore)

2012 - 2013: Integrative analysis of the ongogenic transcription factors, AP-2γ and FoxA1 in breast cancer using nanobiotechnology and genome biology (A*Star JCO funded project)

2011 - 2012: Heterogeneous phase displacement immunoassays for urinary protein markers (Industrial project: IMRE - Nitto Denko Asia Technical Centre Pte. Ltd)

PhD (NUS, Singapore)

2007 - 2011: Supramolecular chemistry and crystal engineering of amino acid Schiff bases

2009 - 2010: Study the effect of site-directed mutagenesis on copper metalloprotein and protein crystallization (188体育网址_188体育在线-【唯一授权网站】@ of Illinois, Urbana-Champaign, USA)

Future 188体育网址_188体育在线-【唯一授权网站】@

Please visit our group webpage:

https://newsy1019.wixsite.com/newgroup

• WONG, ZHENG WEI and NEW, SIU YEE, 2023. An enzyme-free turn-on fluorescent strategy for nucleic acid detection based on hybridization chain reaction and transferable silver nanoclusters MICROCHIMICA ACTA. 190(1),
• OOI, JESSICA SUI YING and NEW, SIU YEE, 2022. Design Strategies of Gold Nanoparticles-Based Biosensors Coupled with Hybridization Chain Reaction or Catalytic Hairpin Assembly CHEMISTRYSELECT. 7(7),
• ZHENG WEI WONG, KASTURI MUTHOOSAMY, NUR ALIANA HIDAYAH MOHAMED and SIU YEE NEW, 2022. A ratiometric fluorescent biosensor based on magnetic-assisted hybridization chain reaction and DNA-templated silver nanoclusters for sensitive microRNA detection Biosensors and Bioelectronics: X. 12, 100244
• XIN YI WONG, DANIEL QUESADA-GONZ?LEZ, SIVAKUMAR MANICKAM, SIU YEE NEW, KASTURI MUTHOOSAMY and ARBEN MERKO?I, 2021. Integrating gold nanoclusters, folic acid and reduced graphene oxide for nanosensing of glutathione based on “turn-off” fluorescence Scientific Reports. 11, 2375
• WONG, ZHENG WEI, NG, JECK FEI and NEW, SIU YEE, 2021. Ratiometric Detection of microRNA Using Hybridization Chain Reaction and Fluorogenic Silver Nanoclusters Chemistry – An Asian Journal. 16(24), 4081-4086
• WAI, JING LUEN and NEW, SIU YEE, 2020. Cysteamine-coated gold nanoparticles for bimodal colorimetric detection with inverse sensitivity: a proof-of-concept with lysozyme RSC ADVANCES. 10(2), 1088-1094
• SHI TING LEE, RUMAN RAHMAN, KASTURI MUTHOOSAMY, NUR ALIANA HIDAYAH MOHAMED, XIAODI SU and SAAD TAYYAB, 2019. Amplification-free and direct fluorometric determination of telomerase activity in cell lysates using chimeric DNA-templated silver nanoclusters Microchimica Acta. 186, 81
• LEE SHI TING, DAVID P BEAUMONT, KASTURI MUTHOOSAMY, SU XIAO DI and NEW SIU YEE, 2018. Formulation of DNA Chimera Templates: Effects on Emission Behavior of Silver Nanoclusters and Sensing Analytica Chimica Acta. 1010, 62-68 (IF = 4.95)
• JIAMIAO HU, SI KEE TAN, MICHELLE GEK LIANG LIM, SHIE HONG CHANG, GUIMEI CUI, SHANSHAN LIU, KAMESH NARASIMHAN, SIU YEE NEW, XUECONG WANG, CONGLING CHEN, HARAPRIYA CHAKRAVARTY, PRASANNA R KOLATKAR, KIN YIP TAM, QIAN LU, XIAODI SU, RALF JAUCH and EDWIN CHEUNG, 2018. Identification of a Wells–Dawson polyoxometalate-based AP-2γ inhibitor with pro-apoptotic activity Biochemical Journal. 475(11), 1965-1977
• LEE SHI TING and NEW SIU YEE, 2017. In-Depth Investigation on DNA-AgNCs Designs for Adenosine Detection In: Second International Conference on Molecular Diagnostics and Biomarker Discovery Conference, Penang, Malaysia.
• WAI JING LUEN and NEW SIU YEE, 2017. Gold Nanoparticles-based Colorimetric Aptasensor for Biomarker Detection In: Second International Conference on Molecular Diagnostics and Biomarker Discovery Conference, Penang, Malaysia.
• NEW SIU YEE and LEE SHI TING, 2017. Formulation of DNA Chimera Templates for Silver Nanoclusters (Invited) In: 25th PolyChar, PWTC, Kuala Lumpur, Malaysia..
• HOSSEINZADEH PARISA, MARSHALL NICHOLAS M., CHAC?N KELLY N., YU YANG, NILGES MARK J., NEW SIU YEE, TASHKOV STOYAN A., BLACKBURN NINIAN J. and LU YI, 2016. Design of a single protein that spans the entire 2-V range of physiological redox potentials Proceedings of the National Academy of Sciences of USA. (IF = ?9.674)
• NEW SIU YEE*, LEE SHI TING and SU XIAO DI, 2016. DNA-templated silver nanoclusters: structural correlation and fluorescence modulation Nanoscale. 8, 17729–17746 (IF = 7.76)
• LEE SHI TING, DAVID BEAUMENT and NEW SIU YEE, 2016. In-Depth Investigation on DNA-AgNCs Designs for Adenosine Detection In: ICONAN, Paris, France.
• NEW SIU YEE and LEE SHI TING, 2016. Formulation of DNA-Templated Silver Nanoclusters: Location of Nucleation Sequence Matters In: Nano2016, Quebec, Canada.
• NEW SIU YEE, KHIN MOH MOH AUNG, YONG YU, XIE JIAN PING, LU YI, TAN YEN NEE, CHEUNG EDWIN and SU XIAO DI, 2015. Gold Nanosensors for Protein-Ligand Interactions In: IUPAC 2015, Busan, Korea.
• YU YONG, NEW SIU YEE, LIN JIAXIAN, SU XIAO DI and TAN YEN NEE, 2015. A Rapid and Quantitative Fluorimetric Method for Protein-Targeting Small Molecule Drug Screening Journal of Visualized Experiments. e53261 (IF = 1.325)
• KHIN MOH MOH AUNG, SIU YEE NEW, SHUZHEN HONG, LAURA SUTARLIE, MICHELLE GEK LIANG LIM, SI KEE TAN, EDWIN CHEUNG and XIAODI SU, 2014. Gold Nanoparticle Colorimetric Assay for 188体育网址_188体育在线-【唯一授权网站】@ FoxA1-DNA Interactions and Ligand Inhibition: A Comparison with EMSA and Fluorescence Anisotropic Assay Analytical Biochemistry. 448, 95-104 (IF= 2.31)
• NEW, SIU YEE, AUNG, KHIN MOH MOH, LIM, GEK LIANG, HONG, SHUZHEN, TAN, SI KEE, LU, YI, CHEUNG, EDWIN and SU, XIAODI, 2014. Fast Screening of Ligand-Protein Interactions based on Ligand-Induced Protein Stabilization of Gold Nanoparticles Analytical Chemistry. 86(5), 2361-2370 (IF= 5.83)
• YU, YONG, NEW, SIU YEE (CONTRIBUTE EQUALLY), XIE, JIANPING, SU, XIAODI and TAN, YEN NEE, 2014. Protein-based fluorescent metal nanoclusters for small molecular drug screening Chemical Communications. (IF= 6.72)
• STEVEN LUKMAN, NEW SIU YEE and CHEUNG EDWIN, 2014. A Hybrid Sensor using Metal Nanoparticles and Conjugated Polymers (USA Patent) 14/275,526 05/12/2014 00:00:00
• NEW, SIU YEE, 2014. The ‘Revival’ of Nanosensors Austin Journal of Biosensors & Bioelectronics (Editorial). 1(1), 1
• NEW SIU YEE, CHEUNG EDWIN and SU XIAO DI, 2013. A Method to screen small ligands and determine protein-ligand interactions (Singapore Patent) 201303835-1 05/16/2013 00:00:00
• NEW SIU YEE, SU XIAO DI and TAN YEN NEE, 2013. Protein-Based Fluorescent Metal Nanoclusters for Drug Screening (Singapore Patent) 201306645-1 09/01/2013 00:00:00
• STEVEN LUKMAN, NEW SIU YEE, CHEUNG EDWIN and SU XIAO DI, 2013. A Hybrid Sensor using Metal Nanoparticles and Conjugated Polymers (Singapore Patent) 201303638-9 05/10/2013 00:00:00
• KE LIN, LIM WAI KWAN, NEW SIU YEE, SU XIAO DI and LIU BIN, 2013. Immunosensor Characterization Using Impedance Spectroscopy Journal of Biosensors & Bioelectronics. 4(4),
• NEW SIU YEE, SU XIAO DI and TAN YEN NEE, 2013. Bovine Serum Albumin Based Gold Nanocluster for Ligand Sensing In: SNIC-RSC Joint Symposium on Inorganic Chemistry, IMRE, Singapore.
• NEW, SIU YEE, MARSHALL, NICHOLAS M., HOR, T. S. ANDY, XUE, FENG and LU, YI, 2012. Redox tuning of two biological copper centers through non-covalent interactions: same trend but different magnitude CHEMICAL COMMUNICATIONS. 48(35), 4217-4219 (IF= 6.72)
• NEW SIU YEE, KHIN MOH MOH AUNG, TAN SI KEE, HONG SU ZHEN, CHEUNG EDWIN and SU XIAO DI, 2012. Gold Nanorods and Nanoparticles Derived Bioassays for Transcription Factors (AP-2γ and FoxA1)-DNA Binding Detection In: XI International Conference on Nanostructured Materials, Nano2012, Rhodes, Greece.
• NEW, SIU YEE, THIO, YUDE, KOH, LIP LIN, HOR, T. S. ANDY and XUE, FENG, 2011. Supramolecular assembly of a new series of copper-L-arginine Schiff bases CRYSTENGCOMM. 13(6), 2114-2122 (IF= 3.86)
• NEW, SIU YEE, WU, XUAN, BAI, SHI-QIANG, KOH, LIP LIN, HOR, T. S. ANDY and XUE, FENG, 2011. Lipid-bilayer-mimicking solid-state structures of Cu(II) and Ni(II) with L-tryptophan and L-tyrosine Schiff base derivatives CRYSTENGCOMM. 13(12), 4228-4235 (IF= 3.86)
• NEW SIU YEE, ANDY HOR TZI SUM and XUE FENG, 2008. Supramolecular Assembly Using Amino Acid Based Schiff Bases In: Inorganic Chemistry Conference (IC08), 188体育网址_188体育在线-【唯一授权网站】@ of Canterbury Christchurch, New Zealand.
• NEW SIU YEE, ANDY HOR TZI SUM and XUE FENG, 2008. Supramolecular Assembly Using Amino Acid Based Schiff Bases In: Singapore-Hong Kong Bilateral Graduate Student Congress, NUS, Singapore.