Contact

• workRoom BA11 B
  Malaysia Campus
  Jalan Broga
  43500 Semenyih
  Selangor Darul Ehsan
  Malaysia
• work+6 (03) 8725 3435
• Premanand.Krishnan@nottingham.edu.my

Teaching Summary

Involved in teaching chemistry modules for Foundation in Science students:

SCIF F029: Chemistry 3 (Module convenor)

SCIF F027: Chemistry 1

188体育网址_188体育在线-【唯一授权网站】@ Summary

Natural product chemistry

My major research interest focuses on discovery of novel natural products from plants, particularly alkaloids and triterpenoids, which possess interesting biological activities. The common activities involved in my research include extraction of plant material, chromatographic isolation of compounds, NMR structure elucidation, chemical modification of natural products, and biological evaluation of pure compounds and derivatives. The various analytical/separation tools employed in my research include NMR, high resolution MS, FT-IR, UV-vis, single crystal X-ray crystallography, circular dichroism, and various chromatographic techniques.

Recent Publications

• CHO, EUN-SEON, KRISHNAN, PREMANAND, LOH, HWEI-SAN, DALY, JANET M., LEONG, CHEE-ONN, MAI, CHUN-WAI, LOW, YUN-YEE, YONG, KIEN-THAI and LIM, KUAN-HON, 2022. Pentacyclic and hexacyclic cucurbitacins from Elaeocarpus petiolatus PHYTOCHEMISTRY. 193,
• LEE, FONG-KAI, KRISHNAN, PREMANAND, MUHAMAD, AZIRA, LOW, YUN-YEE, KAM, TOH-SEOK, TING, KANG-NEE and LIM, KUAN-HON, 2021. Concise synthesis of the vasorelaxant alkaloids schwarzinicines A and B NATURAL PRODUCT RESEARCH.
• CHAN, ZI-YANG, KRISHNAN, PREMANAND, MODARESI, SAYED MOHAMMADHOSSEIN, HII, LING-WEI, MAI, CHUN-WAI, LIM, WEI-MENG, LEONG, CHEE-ONN, LOW, YUN-YEE, WONG, SOON-KIT, YONG, KIEN-THAI, LEONG, ALYSSA ZI-XIN, LEE, MEI-KEE, TING, KANG-NEE and LIM, KUAN-HON, 2021. Monomeric, Dimeric, and Trimeric Tropane Alkaloids from Pellacalyx saccardianus JOURNAL OF NATURAL PRODUCTS. 84(8), 2272-2281
• CHAN, ZI-YANG, KRISHNAN, PREMANAND, HII, LING -WEI, MAI, CHUN-WAI, LEONG, CHEE-ONN, LOW, YUN-YEE, WONG, SOON-KIT, TING, KANG-NEE, YONG, KIEN -THAI and LIM, KUAN-HON, 2021. Unusual diarylheptanoid-phenylpropanoid adducts and diarylheptanoid alkaloids from Pellacalyx saccardianus PHYTOCHEMISTRY LETTERS. 46, 36-44

• View all publications

Past 188体育网址_188体育在线-【唯一授权网站】@

1. Krishnan, P., Lee, F.K., Chong, K.W., Mai, C.W., Muhamad, A., Lim, S.H., Low, Y.Y., Ting, K.N., Lim, K.H., 2018. Alstoscholactine and Alstolaxepine, Monoterpenoid Indole Alkaloids with γ-Lactone-Bridged Cycloheptane and Oxepane Moieties from Alstonia scholaris. Organic Letters doi:10.1021/acs.orglett.8b03592

2. Krishnan, P., Mai, C.-W., Yong, K.-T., Low, Y.-Y., Lim, K.-H., 2019. Alstobrogaline, an unusual pentacyclic monoterpenoid indole alkaloid with aldimine and aldimine-N-oxide moieties from Alstonia scholaris. Tetrahedron Letters doi:10.1016/J.TETLET.2019.02.018

3. Ezeoke, M.C., Krishnan, P., Sim, D.S.-Y., Lim, S.-H., Low, Y.-Y., Chong, K.-W., Lim, K.-H., 2018. Unusual phenethylamine-containing alkaloids from Elaeocarpus tectorius. Phytochemistry 146, 75-81. doi:10.1016/j.phytochem.2017.12.003

4. Al-Khdhairawi, A.A.Q., Krishnan, P., Mai, C.W., Chung, F.F.L., Leong, C.O., Yong, K.T., Chong, K.W., Low, Y.Y., Kam, T.S., Lim, K.H., 2017. A Bis-benzopyrroloisoquinoline Alkaloid Incorporating a Cyclobutane Core and a Chlorophenanthroindolizidine Alkaloid with Cytotoxic Activity from Ficus fistulosa var. tengerensis. Journal of Natural Products 80, 2734-2740. doi:10.1021/acs.jnatprod.7b00500

5. Chan, Z.Y., Govindaraju, K., Krishnan, P., Low, Y.Y., Chong, K.W., Yong, K.T., Ting, K.N., Lim, K.H., 2019. Diphenethylpiperidine alkaloids with tracheal smooth muscle relaxation activity from Hippobroma longiflora (L.) G. Don. Phytochemistry Letters doi:10.1016/j.phytol.2019.01.035

• CHO, EUN-SEON, KRISHNAN, PREMANAND, LOH, HWEI-SAN, DALY, JANET M., LEONG, CHEE-ONN, MAI, CHUN-WAI, LOW, YUN-YEE, YONG, KIEN-THAI and LIM, KUAN-HON, 2022. Pentacyclic and hexacyclic cucurbitacins from Elaeocarpus petiolatus PHYTOCHEMISTRY. 193,
• LEE, FONG-KAI, KRISHNAN, PREMANAND, MUHAMAD, AZIRA, LOW, YUN-YEE, KAM, TOH-SEOK, TING, KANG-NEE and LIM, KUAN-HON, 2021. Concise synthesis of the vasorelaxant alkaloids schwarzinicines A and B NATURAL PRODUCT RESEARCH.
• CHAN, ZI-YANG, KRISHNAN, PREMANAND, MODARESI, SAYED MOHAMMADHOSSEIN, HII, LING-WEI, MAI, CHUN-WAI, LIM, WEI-MENG, LEONG, CHEE-ONN, LOW, YUN-YEE, WONG, SOON-KIT, YONG, KIEN-THAI, LEONG, ALYSSA ZI-XIN, LEE, MEI-KEE, TING, KANG-NEE and LIM, KUAN-HON, 2021. Monomeric, Dimeric, and Trimeric Tropane Alkaloids from Pellacalyx saccardianus JOURNAL OF NATURAL PRODUCTS. 84(8), 2272-2281
• CHAN, ZI-YANG, KRISHNAN, PREMANAND, HII, LING -WEI, MAI, CHUN-WAI, LEONG, CHEE-ONN, LOW, YUN-YEE, WONG, SOON-KIT, TING, KANG-NEE, YONG, KIEN -THAI and LIM, KUAN-HON, 2021. Unusual diarylheptanoid-phenylpropanoid adducts and diarylheptanoid alkaloids from Pellacalyx saccardianus PHYTOCHEMISTRY LETTERS. 46, 36-44
• KRISHNAN, PREMANAND, LEE, FONG-KAI, YAP, VERONICA ALICIA, LOW, YUN-YEE, KAM, TOH-SEOK, KIEN-THAI YONG, TING, KANG-NEE and LIM, KUAN-HON, 2020. Schwarzinicines A-G, 1,4-Diarylbutanoid-Phenethylamine Conjugates from the Leaves of Ficus schwarzii JOURNAL OF NATURAL PRODUCTS. 83(1), 152-158
• KRISHNAN, PREMANAND, MAI, CHUN-WAI, YONG, KIEN-THAI, LOW, YUN-YEE and LIM, KUAN-HON, 2019. Alstobrogaline, an unusual pentacyclic monoterpenoid indole alkaloid with aldimine and aldimine-N-oxide moieties from Alstonia scholaris TETRAHEDRON LETTERS. 60(11), 789-791
• CHAN, ZI-YANG, GOVINDARAJU, KAYATRI, KRISHNAN, PREMANAND, LOW, YUN-YEE, CHONG, KAM-WENG, YONG, KIEN-THAI, TING, KANG-NEE and LIM, KUAN-HON, 2019. Diphenethylpiperidine alkaloids with tracheal smooth muscle relaxation activity from Hippobroma longiflora (L.) G. Don PHYTOCHEMISTRY LETTERS. 30, 93-98
• EZEOKE, M.C., KRISHNAN, P., SIM, D.S.Y., LIM, S.H., LOW, Y.Y., CHONG, K.W. and LIM, K.H., 2018. Unusual phenethylamine-containing alkaloids from Elaeocarpus tectorius Phytochemistry. 146, 75-81
• PREMANAND KRISHNAN, FONG-KAI LEE, KAM-WENG CHONG, CHUN-WAI MAI, AZIRA MUHAMAD, SIEW-HUAH LIM, YUN-YEE LOW, KANG-NEE TING and KUAN-HON LIM, 2018. Alstoscholactine and Alstolaxepine, Monoterpenoid Indole Alkaloids with γ?Lactone-Bridged Cycloheptane and Oxepane Moieties from Alstonia scholaris Organic Letters. 20, 8014-8018